The division initiated its scientific activities as an Entomology Division with main objective to minimize crop losses due to ravages of insect pests, diseases, weeds, nematodes, and rodents. In 2009, it was renamed as Plant Protection Division in which plant pathology section was included. The main focus of this division is to promote eco-friendly management with combination of nuclear techniques to manage insect pests and diseases of major crops and fruits. Its major achievements are, 1) perfected male annihilation technique to manage fruit flies in guava and mango orchards. 2) developed biological control against sugar cane bores and cotton pests, 3) extended the biological control technique with the coordination of 10 private sugar mills in 8 districts of Sind. Now a days female attracting system for fruit flies and management of diseases of wheat, rice sugarcane and cotton are in progress.